Immunometabolic Alterations by HPV Infection: New Dimensions to Head and Neck Cancer Disparity.

ABSTRACT: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer, with high morbidity and mortality. Racial disparity in HNSCC is observed between African Americans (AAs) and whites, effecting both overall and 5-year survival, with worse prognosis for AAs. In addition to socio-economic status and demographic factors, many epidemiological studies have also identified factors including coexisting human papillomavirus (HPV) infection, primary tumor location, and a variety of somatic mutations that contribute to the prognostic incongruities in HNSCC patients among AAs and whites. Recent research also suggests HPV-induced dysregulation of tumor metabolism and immune microenvironment as the major regulators of HNSCC patient prognosis. Outcomes of several preclinical and clinical stu

SUBMITTER: Chaudhary S 

PROVIDER: S-EPMC6410958 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature