Maximum entropy and population heterogeneity in continuous cell cultures.

ABSTRACT: Continuous cultures of mammalian cells are complex systems displaying hallmark phenomena of nonlinear dynamics, such as multi-stability, hysteresis, as well as sharp transitions between different metabolic states. In this context mathematical models may suggest control strategies to steer the system towards desired states. Although even clonal populations are known to exhibit cell-to-cell variability, most of the currently studied models assume that the population is homogeneous. To overcome this limitation, we use the maximum entropy principle to model the phenotypic distribution of cells in a chemostat as a function of the dilution rate. We consider the coupling between cell metabolism and extracellular variables describing the state of the bioreactor and take into account the impact of

SUBMITTER: Fernandez-de-Cossio-Diaz J 

PROVIDER: S-EPMC6411232 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature