An Antiviral Branch of the IL-1 Signaling Pathway Restricts Immune-Evasive Virus Replication.

ABSTRACT: Virulent pathogens often cause the release of host-derived damage-associated molecular patterns (DAMPs) from infected cells. During encounters with immune-evasive viruses that block inflammatory gene expression, preformed DAMPs provide backup inflammatory signals that ensure protective immunity. Whether DAMPs exhibit additional backup defense activities is unknown. Herein, we report that viral infection of barrier epithelia (keratinocytes) elicits the release of preformed interleukin-1 (IL-1) family cytokines, including the DAMP IL-1α. Mechanistic studies revealed that IL-1 acts on skin fibroblasts to induce an interferon (IFN)-like state that restricts viral replication. We identified a branch in the IL-1 signaling pathway that induces IFN-stimulated gene expression in infected cells and

SUBMITTER: Orzalli MH 

PROVIDER: S-EPMC6411291 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature