Integrated transcriptome interactome study of oncogenes and tumor suppressor genes in breast cancer.

ABSTRACT: Breast cancer is the leading cause for mortality among women worldwide. Dysregulation of oncogenes and tumor suppressor genes is the major reason for the cause of cancer. Understanding these genes will provide clues and insights about their regulatory mechanism and their interplay in cancer. In the present study, an attempt is made to compare the functional characteristics and interactions of oncogenes and tumor suppressor genes to understand their biological role. 431 breast cancer samples from seven publicly available microarray datasets were collected and analysed using GEO2R tool. The identified 416 differentially expressed genes were classified into five gene sets as oncogenes (OG), tumor suppressor genes (TSG), druggable genes, essential genes and other genes. The gene sets were subj

SUBMITTER: Pranavathiyani G 

PROVIDER: S-EPMC6411624 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature