Establishment of Novel Murine Model showing Vascular Inflammation-derived Cognitive Dysfunction.

ABSTRACT: Inflammation is a critical feature of aging and its related diseases, including cardiovascular diseases. Recent epidemiological studies demonstrated that abdominal aortic aneurysm (AAA), an aging-related vascular pathological condition, is associated with cognitive decline. However, the underlying mechanism, especially the role of vascular inflammation, is largely unknown because of lack of an available animal model. In this study, we examined whether vascular inflammation affects synaptic and cognitive dysfunction, using an AAA mouse model. In young (3 months) and middle-aged (12 months) C57BL/6J mice, AAA was induced by angiotensin II infusion with calcium chloride application. After 4 weeks of induction, aortic diameter was significantly increased and excessive Mac3-positive inflammator

SUBMITTER: Hashizume T 

PROVIDER: S-EPMC6411753 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature