A Mathematical Analysis of Aerobic Glycolysis Triggered by Glucose Uptake in Cones.

ABSTRACT: Patients affected by retinitis pigmentosa, an inherited retinal disease, experience a decline in vision due to photoreceptor degeneration leading to irreversible blindness. Rod-derived cone viability factor (RdCVF) is the most promising mutation-independent treatment today. To identify pathologic processes leading to secondary cone photoreceptor dysfunction triggering central vision loss of these patients, we model the stimulation by RdCVF of glucose uptake in cones and glucose metabolism by aerobic glycolysis. We develop a nonlinear system of enzymatic functions and differential equations to mathematically model molecular and cellular interactions in a cone. We use uncertainty and sensitivity analysis to identify processes that have the largest effect on the system and their timeframes. W

SUBMITTER: Camacho ET 

PROVIDER: S-EPMC6411757 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature