Intrinsic connectivity networks in posterior cortical atrophy: A role for the pulvinar?

ABSTRACT:

Background

Posterior cortical atrophy (PCA) is a clinical variant of Alzheimer's disease (AD) that presents with progressive visuospatial symptoms. While amnestic AD is characterized by disrupted default mode network (DMN) connectivity with corresponding increases in salience network (SN) connectivity, a visuospatial network appears to be disrupted early in PCA. Based on PCA patients' clinical features, we hypothesized that, in addition to early decreased integrity within the visuospatial network, patients with PCA would show increases in SN connectivity despite relative preservation of DMN. As the lateral pulvinar nucleus of the thalamus has direct anatomical connections with striate and extrastriate cortex and DMN, and the medial pulvinar is anatomically interconnected with SN, w

SUBMITTER: Fredericks CA 

PROVIDER: S-EPMC6411779 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature