Linked MRI signatures of the brain's acute and persistent response to concussion in female varsity rugby players.

ABSTRACT: Acute brain changes are expected after concussion, yet there is growing evidence of persistent abnormalities well beyond clinical recovery and clearance to return to play. Multiparametric MRI is a powerful approach to non-invasively study structure-function relationships in the brain, however it remains challenging to interpret the complex and heterogeneous cascade of brain changes that manifest after concussion. Emerging conjunctive, data-driven analysis approaches like linked independent component analysis can integrate structural and functional imaging data to produce linked components that describe the shared inter-subject variance across images. These linked components not only offer the potential of a more comprehensive understanding of the underlying neurobiology of concussion, but

SUBMITTER: Manning KY 

PROVIDER: S-EPMC6411783 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature