DNA Ligase 1 is an essential mediator of sister chromatid telomere fusions in G2 cell cycle phase.

ABSTRACT: Fusion of critically short or damaged telomeres is associated with the genomic rearrangements that support malignant transformation. We have demonstrated the fundamental contribution of DNA ligase 4-dependent classical non-homologous end-joining to long-range inter-chromosomal telomere fusions. In contrast, localized genomic recombinations initiated by sister chromatid fusion are predominantly mediated by alternative non-homologous end-joining activity that may employ either DNA ligase 3 or DNA ligase 1. In this study, we sought to discriminate the relative involvement of these ligases in sister chromatid telomere fusion through a precise genetic dissociation of functional activity. We have resolved an essential and non-redundant role for DNA ligase 1 in the fusion of sister chromatids bea

SUBMITTER: Liddiard K 

PROVIDER: S-EPMC6411840 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature