The In Vitro Biotransformation of the Fusion Protein Tetranectin-Apolipoprotein A1.

ABSTRACT: As more and more protein biotherapeutics enter the drug discovery pipelines, there is an increasing interest in tools for mechanistic drug metabolism investigations of biologics in order to identify and prioritize the most promising candidates. Understanding or even predicting the in vivo clearance of biologics and to support translational pharmacokinetic modeling activities is essential, however there is a lack of effective and validated in vitro cellular tools. Although different mechanisms have to be adressed in the context of biologics disposition, the scope is not comparable to the nowadays widely established tools for early characterization of small molecule disposition. Here, we describe a biotransformation study of the fusion protein tetranectin apolipoprotein A1 by cellular system

SUBMITTER: Schadt S 

PROVIDER: S-EPMC6411889 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature