Different patterns of white matter changes after successful surgery of mesial temporal lobe epilepsy.

ABSTRACT:

Objectives

To explore the dynamic changes of white matters following anterior temporal lobectomy (ATL) in mesial temporal lobe epilepsy (MTLE) patients who achieved seizure-free at two-year follow-up.

Methods

Diffusion tensor imaging (DTI) was obtained in ten MTLE patients at five serial time points: before surgery, three months, six months, 12 months and 24 months after surgery, as well as in 11 age- and sex-matched healthy controls at one time point. Regions with significant postoperative fractional anisotropy (FA) changes and their dynamic changes were confirmed by comparing all preoperative and postoperative data using Tract-Based Spatial Statistics (TBSS).

Results

After successful ATL, significant FA changes were found in widespread ipsilateral and contralateral

SUBMITTER: Li W 

PROVIDER: S-EPMC6411915 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature