The browning of white adipose tissue and body weight loss in primary hyperparathyroidism.

ABSTRACT:

Background

Parathyroid hormone related protein (PTHrP) triggers white adipose tissue (WAT) browning and cachexia in lung cancer mouse models. It remains unknown whether excessive PTH secretion affects WAT browning and to what extent it contributes to body weight change in primary hyperparathyroidism (PHPT).

Methods

Using the adeno-associated virus injection, Pth gene over-expressed mice mimicking PHPT were firstly established to observe their WAT browning and body weight alteration. The association between PTH and body weight was investigated in 496 PHPT patients. The adipose browning activities of 20 PHPT and 60 control subjects were measured with PET/CT scanning.

Findings

Elevated plasma PTH triggered adipose tissue browning, leading to increased energy expenditure,

SUBMITTER: He Y 

PROVIDER: S-EPMC6412009 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature