Donor-derived cell-free DNA predicts allograft failure and mortality after lung transplantation.

ABSTRACT:

Background

Allograft failure is common in lung-transplant recipients and leads to poor outcomes including early death. No reliable clinical tools exist to identify patients at high risk for allograft failure. This study tested the use of donor-derived cell-free DNA (%ddcfDNA) as a sensitive marker of early graft injury to predict impending allograft failure.

Methods

This multicenter, prospective cohort study enrolled 106 subjects who underwent lung transplantation and monitored them after transplantation for the development of allograft failure (defined as severe chronic lung allograft dysfunction [CLAD], retransplantation, and/or death from respiratory failure). Plasma samples were collected serially in the first three months following transplantation and assayed for %ddcfD

SUBMITTER: Agbor-Enoh S 

PROVIDER: S-EPMC6412014 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature