Longitudinal changes in cocaine intake and cognition are linked to cortical thickness adaptations in cocaine users.

ABSTRACT:

Background

Cocaine use has been consistently associated with decreased gray matter volumes in the prefrontal cortex. However, it is unclear if such neuroanatomical abnormalities depict either pre-existing vulnerability markers or drug-induced consequences. Thus, this longitudinal MRI study investigated neuroplasticity and cognitive changes in relation to altered cocaine intake.

Methods

Surface-based morphometry, cocaine hair concentration, and cognitive performance were measured in 29 cocaine users (CU) and 38 matched controls at baseline and follow-up. Based on changes in hair cocaine concentration, CU were classified either as Decreasers (n = 15) or Sustained Users (n = 14). Surface-based morphometry measures did not include regional tissue volumes.

Results

At basel

SUBMITTER: Hirsiger S 

PROVIDER: S-EPMC6412021 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature