Early life stress delays hippocampal development and diminishes the adult stem cell pool in mice.

ABSTRACT: Early life stress predisposes to mental illness and behavioral dysfunction in adulthood, but the mechanisms underlying these persistent effects are poorly understood. Stress throughout life impairs the structure and function of the hippocampus, a brain system undergoing considerable development in early life. The long-term behavioral consequences of early life stress may therefore be due in part to interference with hippocampal development, in particular with assembly of the dentate gyrus (DG) region of the hippocampus. We investigated how early life stress produces long-term alterations in DG structure by examining DG assembly and the generation of a stable adult stem cell pool in routine housing and after stress induced by the limited bedding/nesting paradigm in mice. We found that early

SUBMITTER: Youssef M 

PROVIDER: S-EPMC6412041 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature