Sensory-motor network functional connectivity in children with unilateral cerebral palsy secondary to perinatal stroke.

ABSTRACT:

Background

Perinatal stroke is the most common cause of unilateral cerebral palsy. Mechanisms of post-stroke developmental plasticity in children are poorly understood. To better understand the relationship between functional connectivity and disability, we used resting-state fMRI to compare sensorimotor connectivity with clinical dysfunction.

Methods

School-aged children with periventricular venous infarction (PVI) and unilateral cerebral palsy were compared to controls. Resting-state BOLD signal was acquired on 3 T MRI and analyzed using CONN in SPM12. Functional connectivity was computed between S1, M1, supplementary motor area (SMA), and thalamus of the left/non-lesioned and right/lesioned hemisphere. Primary outcome was connectivity expressed as a Fisher-transformed cor

SUBMITTER: Woodward KE 

PROVIDER: S-EPMC6412078 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature