Lack of response to disgusting food in the hypothalamus and related structures in Prader Willi syndrome.

ABSTRACT:

Objective

To investigate, based on a putative abnormal neural processing of disgusting signals in Prader Willi syndrome (PWS) patients, the brain response to visual representations of disgusting food in PWS using functional MRI (fMRI).

Methods

Twenty-one genetically-confirmed PWS patients, 30 age- and sex-matched and 28 BMI-matched control subjects viewed a movie depicting disgusting food-related scenes interspersed with scenes of appetizing food while fMRI was acquired. Brain activation maps were compared between groups and correlated with disgust and hunger ratings.

Results

At the cortical level, the response to disgusting food representations in PWS patients was qualitatively similar to that of control subjects, albeit less extensive, and engaged brain regions typi

SUBMITTER: Blanco-Hinojo L 

PROVIDER: S-EPMC6412080 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature