TNF-α is a potential therapeutic target to overcome sorafenib resistance in hepatocellular carcinoma.

ABSTRACT:

Background

The role of tumor necrosis factor alpha (TNF-α) in targeted therapy for hepatocellular carcinoma (HCC) remains largely unknown. The current study aimed to clarify the mechanistic effects of targeting TNF-α to overcome sorafenib resistance in HCC.

Methods

A correlation of TNF-α expression with the prognosis was analyzed in 62 HCC patients who underwent surgical resection and subsequent received adjuvant sorafenib treatment. The relation of TNF-α expression and sorafenib sensitivity was determined in different HCC cell lines. The combined therapeutic effects of sorafenib and ulinastatin, which could inhibit TNF-α expression, on HCC were examined in vitro and in vivo.

Findings

High TNF-α expression was correlated with poor outcomes in HCC patients who received

SUBMITTER: Tan W 

PROVIDER: S-EPMC6412090 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature