Identification of microRNA clusters cooperatively acting on epithelial to mesenchymal transition in triple negative breast cancer.

ABSTRACT: MicroRNAs play important roles in many biological processes. Their aberrant expression can have oncogenic or tumor suppressor function directly participating to carcinogenesis, malignant transformation, invasiveness and metastasis. Indeed, miRNA profiles can distinguish not only between normal and cancerous tissue but they can also successfully classify different subtypes of a particular cancer. Here, we focus on a particular class of transcripts encoding polycistronic miRNA genes that yields multiple miRNA components. We describe 'clustered MiRNA Master Regulator Analysis (ClustMMRA)', a fully redesigned release of the MMRA computational pipeline (MiRNA Master Regulator Analysis), developed to search for clustered miRNAs potentially driving cancer molecular subtyping. Genomically clustere

SUBMITTER: Cantini L 

PROVIDER: S-EPMC6412120 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature