Comprehensive molecular and immunological characterization of hepatocellular carcinoma.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is a heterogeneous disease with various etiological factors, and ranks as the second leading cause of cancer-related mortality worldwide due to multi-focal recurrence. We herein identified three major subtypes of HCC by performing integrative analysis of two omics data sets, and clarified that this classification was closely correlated with clinicopathological factors, immune profiles and recurrence patterns.

Methods

In the test study, 183 tumor specimens surgically resected from HCC patients were collected for unsupervised clustering analysis of gene expression signatures and comparative analysis of gene mutations. These results were validated by using genome, methylome and transcriptome data of 373 HCC patients provided from the Ca

SUBMITTER: Shimada S 

PROVIDER: S-EPMC6412165 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature