Blocking NF-κB Activation in Ly6c⁺ Monocytes Attenuates Necrotizing Enterocolitis.

ABSTRACT: Necrotizing enterocolitis (NEC) is a devastating disease affecting premature infants with intestinal inflammation and necrosis. The neonatal intestinal inflammatory response is rich in macrophages, and blood monocyte count is low in human NEC. We previously found that NF-κB mediates the intestinal injury in experimental NEC. However, the role of NF-κB in myeloid cells during NEC remains unclear. Herein, inhibitor of kappaB kinase β (IKKβ), a critical kinase mediating NF-κB activation, was deleted in lysozyme M (Lysm)-expressing cells, which were found to be Cd11b⁺Ly6c⁺ monocytes but not Cd11b⁺Ly6c^- macrophages in the dam-fed neonatal mouse intestine. NEC induced differentiation of monocytes into intestinal macrophages and up-regulation of monocyt

SUBMITTER: Managlia E 

PROVIDER: S-EPMC6412404 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature