Metal-Free Alpha Trifluoromethylselenolation of Carbonyl Derivatives under Batch and Flow Conditions.

ABSTRACT: Trifluoromethylselenolated carbonyl compounds represent an emerging class with potential applications in several fields; however, a widespread use of such compound is hampered by the very limited number of strategies for their preparation. In this study we developed a method for the preparation of α-SeCF₃ substituted carbonyl derivatives using an in situ generated electrophilic ClSeCF₃ species. We also implemented an in-flow protocol to improve the safety features of the process.

SUBMITTER: Massolo E 

PROVIDER: S-EPMC6412565 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature