Daphnetin: A Novel Anti-Helicobacter pylori Agent.

ABSTRACT:

Background

Antibiotic-resistant H. pylori was increasingly found in infected individuals, which resulted in treatment failure and required alternative therapeutic strategies. Daphnetin, a coumarin-derivative compound, has multiple pharmacological activities.

Methods

The mechanism of daphnetin on H. pylori was investigated focusing on its effect on cell morphologies, transcription of genes related to virulence, adhesion, and cytotoxicity to human gastric epithelial (GES-1) cell line.

Results

Daphnetin showed good activities against multidrug resistant (MDR) H. pylori clinical isolates, with minimal inhibitory concentration (MIC) values ranging from 25 to 100 μg/mL. In addition, daphnetin exposure resulted in H. pylori morphological changes.

SUBMITTER: Wang G 

PROVIDER: S-EPMC6412720 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature