Start Codon Recognition in Eukaryotic and Archaeal Translation Initiation: A Common Structural Core.

ABSTRACT: Understanding molecular mechanisms of ribosomal translation sheds light on the emergence and evolution of protein synthesis in the three domains of life. Universally, ribosomal translation is described in three steps: initiation, elongation and termination. During initiation, a macromolecular complex assembled around the small ribosomal subunit selects the start codon on the mRNA and defines the open reading frame. In this review, we focus on the comparison of start codon selection mechanisms in eukaryotes and archaea. Eukaryotic translation initiation is a very complicated process, involving many initiation factors. The most widespread mechanism for the discovery of the start codon is the scanning of the mRNA by a pre-initiation complex until the first AUG codon in a correct context is fo

SUBMITTER: Schmitt E 

PROVIDER: S-EPMC6412873 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature