Unveiling Mesenchymal Stromal Cells' Organizing Function in Regeneration.

ABSTRACT: Regeneration is a fundamental process attributed to the functions of adult stem cells. In the last decades, delivery of suspended adult stem cells is widely adopted in regenerative medicine as a leading means of cell therapy. However, adult stem cells cannot complete the task of human body regeneration effectively by themselves as far as they need a receptive microenvironment (the niche) to engraft and perform properly. Understanding the mechanisms underlying mammalian regeneration leads us to an assumption that improved outcomes of cell therapy require a specific microenvironment that is generated in damaged areas prior to stem cell delivery. To a certain extent, it may be achieved by the delivery of mesenchymal stromal cells (MSCs), not in dispersed form, but rather in self-organized cel

SUBMITTER: Nimiritsky PP 

PROVIDER: S-EPMC6413004 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature