XPG Asp1104His polymorphism increases colorectal cancer risk especially in Asians.

ABSTRACT: Xeroderma pigmentosum group G (XPG) protein is a pivotal element of the nucleotide excision repair pathway. XPG gene single nucleotide polymorphisms (SNPs) have been shown to confer colorectal cancer (CRC) susceptibility. In this study, we further investigated the role of Asp1104His (rs17655 G > C) in XPG on CRC risk. We genotyped the rs17655 G > C polymorphism in Chinese population comprising 1019 CRC cases and 1036 cancer-free controls. We also performed a meta-analysis to further assess the association. Overall, no significant association was detected between the rs17655 G > C and the risk of CRC. Stratified analysis also revealed no significant association. To further elucidate the association of the rs17655 with CRC susceptibility, we conducted a meta-analysis by includi

SUBMITTER: Su J 

PROVIDER: S-EPMC6413257 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature