O-glycans truncation modulates gastric cancer cell signaling and transcription leading to a more aggressive phenotype.

ABSTRACT:

Background

Changes in glycosylation are known to play critical roles during gastric carcinogenesis. Expression of truncated O-glycans, such as the Sialyl-Tn (STn) antigen, is a common feature shared by many cancers and is associated with cancer aggressiveness and poor-prognosis.

Methods

Glycoengineered cell lines were used to evaluate the impact of truncated O-glycans in cancer cell biology using in vitro functional assays, transcriptomic analysis and in vivo models. Tumor patients 'samples and datasets were used for clinical translational significance evaluation.

Findings

In the present study, we demonstrated that gastric cancer cells expressing truncated O-glycans display major phenotypic alterations associated with higher cell motility and cell invasion. Noteworthy

SUBMITTER: Freitas D 

PROVIDER: S-EPMC6413340 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature