Novel O-alkyl Derivatives of Naringenin and Their Oximes with Antimicrobial and Anticancer Activity.

ABSTRACT: In our investigation, we concentrated on naringenin (NG)-a widely studied flavanone that occurs in citrus fruits. As a result of a reaction with a range of alkyl iodides, 7 novel O-alkyl derivatives of naringenin (7a⁻11a, 13a, 17a) were obtained. Another chemical modification led to 9 oximes of O-alkyl naringenin derivatives (7b⁻13b, 16b⁻17b) that were never described before. The obtained compounds were evaluated for their potential antibacterial activity against Escherichia coli, Staphylococcus aureus, and Bacillus subtilis. The results were reported as the standard minimal inhibitory concentration (MIC) values and compared with naringenin and its known O-alkyl derivatives. Compounds <

SUBMITTER: Kozlowska J 

PROVIDER: S-EPMC6413393 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature