SNP Variation of RELN Gene and Schizophrenia in a Chinese Population: A Hospital-Based Case-Control Study.

ABSTRACT: Aims: We aimed to explore whether RELN contributes to the vulnerability and severity of clinical symptoms of schizophrenia (SZ) in a Chinese population. Methods: The following were conducted in an adult Han Chinese population from southern China: case-control association analyses of 30 representative single nucleotide polymorphisms (SNPs) that were screened according to specific programs based on bioinformatics tools and former research and quantitative trait locus analyses with SNPs and psychiatric symptoms evaluated with the positive and negative symptoms scale. Results: A 4-SNP haplotype consisting of rs362814, rs39339, rs540058, and rs661575 was found to be significantly associated with SZ even after Bonferroni correction (χ² = 29.024, p =

SUBMITTER: Luo X 

PROVIDER: S-EPMC6413413 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature