Among older adults, age-related changes in the stool microbiome differ by HIV-1 serostatus.

ABSTRACT:

Background

HIV-1 infection and physiological aging are independently linked to elevated systemic inflammation and changes in enteric microbial communities (dysbiosis). However, knowledge of the direct effect of HIV infection on the aging microbiome and potential links to systemic inflammation is lacking.

Methods

In a cross-sectional study of older people living with HIV (PLWH) (median age 61.5 years, N = 14) and uninfected controls (median 58 years, n = 22) we compared stool microbiota, levels of microbial metabolites (short-chain fatty acid levels, SCFA) and systemic inflammatory biomarkers by HIV serostatus and age.

Findings

HIV and age were independently associated with distinct changes in the stool microbiome. For example, abundances of Enterobacter and Paraprevot

SUBMITTER: Liu J 

PROVIDER: S-EPMC6413415 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature