Tumor cells induce LAMP2a expression in tumor-associated macrophage for cancer progression.

ABSTRACT:

Background

Tumor cells benefit from tumor-associated macrophages (TAMs) promoting tumor growth and modulating functions of other cells in tumor microenvironment (TME). However, how tumor cells regulate the property of TAMs during tumor invasion remains to be defined.

Methods

Mouse tumor models and cancer patients' samples were analyzed to determine LAMP2a expression in TAMs. In vitro mouse primary macrophages were used to assess LAMP2a-modulated macrophage activation, and to verify LAMP2a's target proteins. The effect of LAMP2a-knockdown on tumor progression and TME maintaining was determined by using mouse tumor models.

Findings

Lysosome associated membrane protein type 2A (LAMP2a) is upregulated in TAMs by tumor cells and important for tumor progression. LAMP2a expr

SUBMITTER: Wang R 

PROVIDER: S-EPMC6413476 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature