Personalized pathology maps to quantify diffuse and focal brain damage.

ABSTRACT:

Background and objectives

Quantitative MRI (qMRI) permits the quantification of brain changes compatible with inflammation, degeneration and repair in multiple sclerosis (MS) patients. In this study, we propose a new method to provide personalized maps of tissue alterations and longitudinal brain changes based on different qMRI metrics, which provide complementary information about brain pathology.

Methods

We performed baseline and two-years follow-up on (i) 13 relapsing-remitting MS patients and (ii) four healthy controls. A group consisting of up to 65 healthy controls was used to compute the reference distribution of qMRI metrics in healthy tissue. All subjects underwent 3T MRI examinations including T1, T2, T2* relaxation and Magnetization Transfer Ratio (MTR) imaging. W

SUBMITTER: Bonnier G 

PROVIDER: S-EPMC6413479 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature