Current perspectives in assessing humoral immunity after measles vaccination.

ABSTRACT:

Introduction

Repeated measles outbreaks in countries with relatively high vaccine coverage are mainly due to failure to vaccinate and importation; however, cases in immunized individuals exist raising questions about suboptimal measles vaccine-induced humoral immunity and/or waning immunity in a low measles-exposure environment.

Areas covered

The plaque reduction neutralization measurement of functional measles-specific antibodies correlates with protection is the gold standard in measles serology, but it does not assess cellular-immune or other parameters that may be associated with durable and/or protective immunity after vaccination. Additional correlates of protection and long-term immunity and new determinants/signatures of vaccine responsiveness such as specific CD46 a

SUBMITTER: Haralambieva IH 

PROVIDER: S-EPMC6413513 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature