Exploratory metabolomic study to identify blood-based biomarkers as a potential screen for colorectal cancer.

ABSTRACT:

Introduction

colorectal cancer (CRC) continues to be difficult to diagnose due to the lack of reliable and predictive biomarkers.

Objective

to identify blood-based biomarkers that can be used to distinguish CRC cases from controls.

Methods

a workflow for untargeted followed by targeted metabolic profiling was conducted on the plasma samples of 26 CRC cases and ten healthy volunteers (controls) using liquid chromatography-mass spectrometry (LCMS). The data acquired in the untargeted scan was processed and analyzed using MarkerView™ software. The significantly different ions that distinguish CRC cases from the controls were identified using a mass-based human metabolome search. The result was further used to inform the targeted scan workflow.

Results

the untarget

SUBMITTER: Asante I 

PROVIDER: S-EPMC6413524 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature