Dietary restriction and gonadal signaling differentially regulate post-development quality control functions in Caenorhabditis elegans.

ABSTRACT: Protein homeostasis is remodeled early in Caenorhabditis elegans adulthood, resulting in a sharp decline in folding capacity and reduced ability to cope with chronic and acute stress. Endocrine signals from the reproductive system can ameliorate this proteostatic collapse and reshape the quality control network. Given that environmental conditions, such as food availability, impact reproductive success, we asked whether conditions of dietary restriction (DR) can also reverse the decline in quality control function at the transition to adulthood, and if so, whether gonadal signaling and dietary signaling remodel the quality control network in a similar or different manner. For this, we employed the eat-2 genetic model and bacterial deprivation protocol. We found that animals under DR mainta

SUBMITTER: Shpigel N 

PROVIDER: S-EPMC6413660 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature