Hyperoxygenation revitalizes Alzheimer's disease pathology through the upregulation of neurotrophic factors.

ABSTRACT: Alzheimer's disease (AD) is a neurodegenerative disease characterized by Aβ-induced pathology and progressive cognitive decline. The incidence of AD is growing globally, yet a prompt and effective remedy is not available. Aging is the greatest risk factor for AD. Brain aging proceeds with reduced vascularization, which can cause low oxygen (O₂ ) availability. Accordingly, the question may be raised whether O₂ availability in the brain affects AD pathology. We found that Tg-APP/PS1 mice treated with 100% O₂ at increased atmospheric pressure in a chamber exhibited markedly reduced Aβ accumulation and hippocampal neuritic atrophy, increased hippocampal neurogenesis, and profoundly improved the cognitive deficits on the multiple behavioral test paradigms. Hyper

SUBMITTER: Choi J 

PROVIDER: S-EPMC6413661 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature