MiR-652-3p inhibition enhances endothelial repair and reduces atherosclerosis by promoting Cyclin D2 expression.

ABSTRACT:

Background

Atherosclerosis is a hyperlipidemia-induced condition affecting the arterial wall that damages healthy endothelial cell (EC) function, leading to enhanced risk of atherothrombotic events. Certain microRNAs regulate EC dysfunction in response to hyperlipidemia and may be suitable therapeutic targets to combat atherosclerosis.

Methods

miRNA expression in human ECs was analyzed under various conditions to identify key microRNAs. High-cholesterol diet (HCD)-fed Mir652^-/-Apoe^-/- (Mir652^-/-) mice and matching Mir652^+/+Apoe^-/- (Mir652^+/+) mice were subjected to carotid injury to analyze the effects of miR-652 knockdown on endothelial repair. In silico analysis followed by in vitro and in vivo experiments w

SUBMITTER: Huang R 

PROVIDER: S-EPMC6413686 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature