Polypropylene mesh implantation for hernia repair causes myeloid cell-driven persistent inflammation.

ABSTRACT: Polypropylene meshes that are commonly used for inguinal hernia repair may trigger granulomatous foreign body reactions. Here, we show that asymptomatic patients display mesh-associated inflammatory granulomas long after surgery, which are dominated by monocyte-derived macrophages expressing high levels of inflammatory activation markers. In mice, mesh implantation by the onlay technique induced rapid and strong myeloid cell accumulation, without substantial attenuation for up to 90 days. Myeloid cells segregated into distinct macrophage subsets with separate spatial distribution, activation profiles, and functional properties, showing a stable inflammatory phenotype in the tissue surrounding the biomaterial and a mixed, wound-healing phenotype in the surrounding stromal tissue. Protein ma

SUBMITTER: Heymann F 

PROVIDER: S-EPMC6413778 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature