Clinical validation of an evidence-based method to adjust Pancreatic Enzyme Replacement Therapy through a prospective interventional study in paediatric patients with Cystic Fibrosis.

ABSTRACT:

Background

A method to adjust Pancreatic Enzyme Replacement Therapy in Cystic Fibrosis is not currently available.

Objectives

To assess the in vivo efficacy of a method to adjust the dose of enzymatic supplement in CF extrapolated from previous in vitro digestion studies (theoretical optimal dose, TOD). Secondly, to assess how individual patient characteristics influence the expected coefficient of fat absorption (CFA) and thus to identify an individual correction factor to improve TOD.

Methods

A prospective interventional study in 43 paediatric patients with CF from 5 European centres. They followed a 24h fixed diet with the theoretical optimal dose for each meal. Faecal collection was carried out between colorimetric markers in order to include all the faeces corres

SUBMITTER: Calvo-Lerma J 

PROVIDER: S-EPMC6413926 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature