Parasite specific 7SL-derived small RNA is an effective target for diagnosis of active trypanosomiasis infection.

ABSTRACT: Human and animal African trypanosomiasis (HAT & AAT, respectively) remain a significant health and economic issue across much of sub-Saharan Africa. Effective control of AAT and potential eradication of HAT requires affordable, sensitive and specific diagnostic tests that can be used in the field. Small RNAs in the blood or serum are attractive disease biomarkers due to their stability, accessibility and available technologies for detection. Using RNAseq, we have identified a trypanosome specific small RNA to be present at high levels in the serum of infected cattle. The small RNA is derived from the non-coding 7SL RNA of the peptide signal recognition particle and is detected in the serum of infected cattle at significantly higher levels than in the parasite, suggesting active processing

SUBMITTER: Chiweshe SM 

PROVIDER: S-EPMC6413958 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature