Mapping water exchange across the blood-brain barrier using 3D diffusion-prepared arterial spin labeled perfusion MRI.

ABSTRACT:

Purpose

To present a novel MR pulse sequence and modeling algorithm to quantify the water exchange rate (k_w ) across the blood-brain barrier (BBB) without contrast, and to evaluate its clinical utility in a cohort of elderly subjects at risk of cerebral small vessel disease (SVD).

Methods

A diffusion preparation module with spoiling of non-Carr-Purcell-Meiboom-Gill signals was integrated with pseudo-continuous arterial spin labeling (pCASL) and 3D gradient and spin echo (GRASE) readout. The tissue/capillary fraction of the arterial spin labeling (ASL) signal was separated by appropriate diffusion weighting (b = 50 s/mm² ). k_w was quantified using a single-pass approximation (SPA) model with total generalized variation (TGV) regularization. Ni

SUBMITTER: Shao X 

PROVIDER: S-EPMC6414249 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature