Simultaneous proton resonance frequency shift thermometry and T₁ measurements using a single reference variable flip angle T₁ method.

ABSTRACT:

Purpose

Implement simultaneous proton resonance frequency (PRF) shift and T₁ measurements with equivalent temporal resolution using a single reference variable flip angle method. This novel method allows for simultaneous thermometry in both aqueous and fatty tissue.

Methods

This method acquires a single reference image at the lower flip angle and all dynamic images at the higher angle. T₁ is calculated using a single reference variable flip angle method, which accounts for the reference image temperature remaining constant. Monte Carlo simulations determined the optimal dynamic flip angle for combined PRF and T₁ measurements. This method was evaluated in MR-guided focused ultrasound heating experiments using a gelatin phantom and human cadave

SUBMITTER: Svedin BT 

PROVIDER: S-EPMC6414269 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature