Changes in arterial cerebral blood volume during lower body negative pressure measured with MRI.

ABSTRACT: Cerebral Autoregulation (CA), defined as the ability of the cerebral vasculature to maintain stable levels of blood flow despite changes in systemic blood pressure, is a critical factor in neurophysiological health. Magnetic resonance imaging (MRI) is a powerful technique for investigating cerebrovascular function, offering high spatial resolution and wide fields of view (FOV), yet it is relatively underutilized as a tool for assessment of CA. The aim of this study was to demonstrate the potential of using MRI to measure changes in cerebrovascular resistance in response to lower body negative pressure (LBNP). A Pulsed Arterial Spin Labeling (PASL) approach with short inversion times (TI) was used to estimate cerebral arterial blood volume (CBV_a) in eight healthy subjects at base

SUBMITTER: Whittaker JR 

PROVIDER: S-EPMC6414398 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature