Polygenic risk and hazard scores for Alzheimer's disease prediction.

ABSTRACT:

Objective

Genome-wide association studies (GWAS) have identified over 30 susceptibility loci associated with Alzheimer's disease (AD). Using AD GWAS data from the International Genomics of Alzheimer's Project (IGAP), Polygenic Risk Score (PRS) was successfully applied to predict life time risk of AD development. A recently introduced Polygenic Hazard Score (PHS) is able to quantify individuals with age-specific genetic risk for AD. The aim of this study was to quantify the age-specific genetic risk for AD with PRS and compare the results generated by PRS with those from PHS.

Methods

Quantification of individual differences in age-specific genetic risk for AD identified by the PRS, was performed with Cox Regression on 9903 (2626 cases and 7277 controls) individuals from the G

SUBMITTER: Leonenko G 

PROVIDER: S-EPMC6414493 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature