Altered proteome of high-density lipoproteins from paediatric acute lymphoblastic leukemia survivors.

ABSTRACT: Acute lymphoblastic leukemia (ALL) is the most frequent malignancy in children. With the use of more modern, efficient treatments, 5-year survival has reached more than 90% in this population. However, this achievement comes with many secondary and long-term effects since more than 65% of the survivors experience at least one severe complication, including the metabolic syndrome and cardiovascular diseases. The main objective of the present work was to characterize the composition of HDL particles isolated from pediatric ALL survivors. HDLs from 8 metabolically healthy ALL survivors, 8 metabolically unhealthy ALL survivors and 8 age- and gender-matched controls were analyzed. The HDL fraction from the survivors contained less cholesterol than the controls. In addition, proteomic analyses r

SUBMITTER: Fournier M 

PROVIDER: S-EPMC6414624 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature