Actomyosin contractility-dependent matrix stretch and recoil induces rapid cell migration.

ABSTRACT: Cells select from a diverse repertoire of migration strategies. Recent developments in tunable biomaterials have helped identify how extracellular matrix properties influence migration, however, many settings lack the fibrous architecture characteristic of native tissues. To investigate migration in fibrous contexts, we independently varied the alignment and stiffness of synthetic 3D fiber matrices and identified two phenotypically distinct migration modes. In contrast to stiff matrices where cells migrated continuously in a traditional mesenchymal fashion, cells in deformable matrices stretched matrix fibers to store elastic energy; subsequent adhesion failure triggered sudden matrix recoil and rapid cell translocation. Across a variety of cell types, traction force measurements revealed

SUBMITTER: Wang WY 

PROVIDER: S-EPMC6414652 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature