Live imaging of alveologenesis in precision-cut lung slices reveals dynamic epithelial cell behaviour.
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ABSTRACT:
SUBMITTER: Akram KM
PROVIDER: S-EPMC6414680 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
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Live imaging of alveologenesis in precision-cut lung slices reveals dynamic epithelial cell behaviour.
Akram Khondoker M KM Yates Laura L LL Mongey Róisín R Rothery Stephen S Gaboriau David C A DCA Sanderson Jeremy J Hind Matthew M Griffiths Mark M Dean Charlotte H CH
Nature communications 20190312 1
Damage to alveoli, the gas-exchanging region of the lungs, is a component of many chronic and acute lung diseases. In addition, insufficient generation of alveoli results in bronchopulmonary dysplasia, a disease of prematurity. Therefore visualising the process of alveolar development (alveologenesis) is critical for our understanding of lung homeostasis and for the development of treatments to repair and regenerate lung tissue. Here we show live alveologenesis, using long-term, time-lapse imagi ...[more]
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