The m⁶A‑methylase complex and mRNA export.

ABSTRACT: During synthesis, mRNA undergoes a number of modifications such as capping, splicing and polyadenylation. These processes are coupled with the orderly deposition of the TREX complex on the mRNA and subsequent recruitment of the NXF1-P15 heterodimer which stimulates the nuclear export of mature mRNAs. mRNAs also undergo a number of internal modifications, the most common of which is the N⁶‑methyladenosine (m⁶A) modification. In this review we discuss the recent evidence of coupling between the m⁶A modification, RNA processing and export.

SUBMITTER: Lesbirel S 

PROVIDER: S-EPMC6414750 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature