Preparation of Water-soluble Polyion Complex (PIC) Micelles Covered with Amphoteric Random Copolymer Shells with Pendant Sulfonate and Quaternary Amino Groups.

ABSTRACT: An amphoteric random copolymer (P(SA)₉₁) composed of anionic sodium 2-acrylamido-2-methylpropanesulfonate (AMPS, S) and cationic 3-acrylamidopropyl trimethylammonium chloride (APTAC, A) was prepared via reversible addition-fragmentation chain transfer (RAFT) radical polymerization. The subscripts in the abbreviations indicate the degree of polymerization (DP). Furthermore, AMPS and APTAC were polymerized using a P(SA)₉₁ macro-chain transfer agent to prepare an anionic diblock copolymer (P(SA)₉₁S₆₇) and a cationic diblock copolymer (P(SA)₉₁A₈₈), respectively. The DP was estimated from quantitative 13C NMR measurements. A stoichiometrically charge neutralized mixture of the aqueous P(SA)₉₁S₆₇ and P(SA)

SUBMITTER: Nakahata R 

PROVIDER: S-EPMC6415021 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature