Assessing Mucoadhesion in Polymer Gels: The Effect of Method Type and Instrument Variables.

ABSTRACT: The process of mucoadhesion has been widely studied using a wide variety of methods, which are influenced by instrumental variables and experiment design, making the comparison between the results of different studies difficult. The aim of this work was to standardize the conditions of the detachment test and the rheological methods of mucoadhesion assessment for semisolids, and introduce a texture profile analysis (TPA) method. A factorial design was developed to suggest standard conditions for performing the detachment force method. To evaluate the method, binary polymeric systems were prepared containing poloxamer 407 and Carbopol 971P®, Carbopol 974P®, or Noveon® Polycarbophil. The mucoadhesion of systems was evaluated, and the reproducibility of these measurements investigated. This d

SUBMITTER: Bassi da Silva J 

PROVIDER: S-EPMC6415125 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature